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found that Iran had the highest prevalence of NAFLD at 40.8% [13]

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All of these factors can contribute to poor production of glutathione (or of the enzymes that help glutathione to do its work), and many also deplete the GSH that the cells produce (by converting it into GSSG)

For these proteins, the cysteine residues, which form intramolecular disulfide bonds, are in a reduced state when coordinated to a zinc ion (Zn 2+ ), and zinc is released upon oxidation of the thiols

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Increasing evidence points to oxidative stress, mediated by free radicals such as ROS and RNS, as a critical factor in the pathogenesis of these diseases [40]