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Hormonal changes can trigger overproduction of melanin in the body, leading to large areas of darkened skin

The Role of Glutathione in the Body Glutathione forms the core nutrients supporting numerous effective bodily functions

(StatPearls Publishing, 2023)

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Strategies such as combining copper ionophores with ferroptosis inducers, or superimposing DSF/Cu regimens on a background of GSH depletion or p53 activation, could overcome resistance to single-death modalities and deliver a potent ferroptosis-cuproptosis double punch to OSCC