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Commercial payer rates typically range from 120 to 250 percent of the stated Medicare rate

10.1016/s1368-8375(98)00110-9 231 SchmiererB.HillC

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Consequently, the development of agents with high CNS bioavailability, selective target engagement, and minimal adverse effects, confirmed by well-powered, stage-stratified clinical trials, will therefore be necessary to determine their clinical utility, even though inducers and NLRP3 inhibitors continue to be promising candidates for disease-modifying therapy

Lung function phenotypes can neither distinguish between obstruction in the small airways and emphysematous destruction of the lung parenchyma nor provide information about regional differences in disease severity