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On a broader level, protein-bound supersulfides are reduced to regenerate protein thiols, a process that is primarily mediated by the depersulfidation capability of the thioredoxin (Trx) and thioredoxin reductase (TrxR) systems [47,48]

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Recently, these were used to create therapeutic cancer vaccines, which are developing as part of a unique anticancer method that uses particular antigens to activate and modify the antitumor immune response through dendritic cells [393]

Acknowledgements The authors thank University Malaya, Universiti Malaya Centre for Addiction Science Studies (UMCAS) and Glami Lemi Biotechnology Research Centre (PPBGL) Universiti Malaya for their continuous support in conducting this study

HGF/c-Met signaling, which is mainly mediated by the RASMAPK and PI3KAKT pathways, affects gene expression and cell cycle progression through the binding of transcription factors, such as the ETS family