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Inflammatory conditions such as rheumatoid arthritis and lupus further elevate risk by causing chronic joint inflammation, which weakens the supportive structures around the big toe

The architecture of NLRP1 is similar to that of NLRP3, with the main difference being that NLRP1 has an additional CT function-to-find domain followed by a C-terminal caspase recruitment domain (CARD) (Wang et al., 2021a)

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Blocking the biological activity of IL-18 in mice by IL-18 binding protein (a natural antagonist of IL-18), can ameliorate APAP-induced acute liver injury [181]

Li N, Li X, Ding Y, Liu X, Diggle K, Kisseleva T, Brenner DA

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