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Gut microbiota modulation The GI tract hosts a dense and diverse community of microorganisms that play a critical role in maintaining digestive health, regulating immunity, synthesizing vitamins, metabolizing indigestible substrates, and maintaining the mucosal barrier

The enzymatic activity and transcript abundance of glutathione peroxidases, which convert GSH to GSSG when the enzyme detoxifies ROS, increased in infested resistant plants

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Since the supply of cysteine is crucial for preventing ferroptosis, restricting cysteine metabolism significantly impairs the oxidative stress defense mechanisms of tumor cells, and increases their susceptibility to cell death [8]

In addition, computational models could be used to predict CNS side effects [138]

Furthermore, both in vitro and in vivo investigations suggest that propolis may protect vascular endothelial function due to its antiproliferative activity