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Anti-inflammatory and anti-tumor effects can be provided by upregulating OXPHOS to treat inflammatory diseases and cancer

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As we performed multiple comparisons in this meta-analysis for 45 times, the p -value which was less than 0.05/50 (0.001) indicated statistical significance after Bonferroni correction

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The aging process is marked by a gradual yet progressive decline in the functional capacity of multiple organs, impairing their ability to sustain baseline tissue homeostasis and adequately respond to physiological demands under stress ( 3.5 Chemotherapy-induced renal injury 3.5.1 Cisplatin-induced nephrotoxicity Cisplatin (CP) is a prominent chemotherapeutic agent utilized in the treatment of solid tumors ( 3.5.2 Methotrexate-induced renal injury Methotrexate (MTX), a potent anti-metabolite and folate antagonist, is administered at elevated doses for the treatment of various cancers, while lower doses are utilized for managing non-malignant conditions ( 3.5.3 Doxorubicin-induced renal intoxication Doxorubicin (DOX), a chemotherapeutic agent classified as an anthracycline, is a highly effective therapeutic used in the management of various hematological cancers and solid tumors ( 2 O 2 ), while concurrently reducing catalase (CAT) activity in the kidneys