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Multiple cellular processes are considered to contribute to this functional decline and these are collectively referred to as the hallmarks of aging and these include processes like genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis 1

However, it was able to reduce H 2 O 2 , nitrite (NO 2 ), and nitrate (NO 3 ) levels in exhaled air condensate, indicating its anti-inflammatory potential [121]

Notably, our prior work and other published studies have demonstrated that MDA-MB-231 and MCF-7-Adr cells exhibit stronger stemness and migratory capacity compared to other breast cancer cell subtypes

Moreover, the senescence phenotype depends on specific pathologies or tissues, making the identification of selective markers essential for the development of new senolytic drug families

In this context, miRNA146a, which is present in the brain in large amounts, has been implicated in APOE4-induced neuroinflammation

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