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MATERIALS AND METHODS Animals: Age-matched male Sprague-Dawley rats (Envigo, Indianapolis, IN) and Syrian hamsters (Charles River Laboratories, Wilmington, MA) were fed either high (HS) salt diet (4.0% NaCl), or a high salt diet fortified with Protandim (4.0% NaCl + ~60 mg/kg/day Protandim) for 1014 days