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Until recently, oral glutathione was thought to be ineffective at raising intracellular levels of glutathione, due to the molecules being lost during digestion

This agrees with interventional (De Jong et al, 1999b

doi: 10.1186/s12958-015-0032-1 2 Vander BorghtMWynsC

If this is the case, it may help to start slowly at a reduced dose and work up to the recommended amount

SOD rs4880 was associated with increased reactive oxygen species (ROS) [87, 88], which may play a role in the reduced brain volume