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On the other hand, the treatment policity estimand was used to evaluate the treatment effect for all randomized participants regardless of whether the trial was discontinued early or rescue medicien was used [2]

Sarbassov et al, 2004

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Figure 1 Oxidative stress OS refers to the imbalance of pro-oxidants and antioxidants and the disruption of redox signaling and control ( Radiotherapy-induced oxidative stress Oxidative stress and ROS may be the main cause of ionizing radiation (IR)-induced cardiotoxicity ( Myocardial fibrosis is a late manifestation of radiation-induced heart disease (RIHD) (50)

Two modes of action of the histone hyperacetylation have been proposed and are not mutually exclusive

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