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Ferroptosis in Ischemic Stroke Cellular Metabolic Mechanism of Ferroptosis Ferroptosis can be initiated through two major pathways: the extrinsic, or transporter-dependent pathway, and the intrinsic, or enzyme regulated pathway

All experiments were independently repeated three times with similar results

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3 The mechanism of ferroptosis Ferroptosis is a nonapoptotic and iron-dependent form of cell death closely related to abnormal cellular energy metabolism induced by the toxic accumulation of lipid peroxides on cellular membranes

(Shanghai) 45 , 5160 (2013)

ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps