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Under hypoxic conditions, the inactivation of PHD2 in human PAECs increases HIF-2, thereby enhancing NAMPT promoter activity to raise the expression of Snail1 and decrease the expression of PECAM1, ultimately inducing EndMT

Additionally, synthetic agents targeting Janus-activated kinase (JAK) inhibitors and cell therapies utilizing mesenchymal stem cells (MSCs) have been incorporated into RA treatment protocols (2931)

Acknowledgments Liron Avrami, GDI, for graphical support Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

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Recent research indicates that vitamin E treatment for atopic dermatitis participants results in decreased blood levels of immunoglobulin E and improved eczema