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Additionally, by activating caspase 1 and cleaving pro-IL-1 and pro-IL-18 to generate IL-1 and IL-18, respectively, ATM and DNA-PKcs support AIM2 inflammasome activation [146, 147]

This lack of activity may be due to loss of hydrophobic interactions, but it is also possible that the methyl group affects the conformation of the amide and leads to disruption of the H-bond between the carbonyl and T336