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doi: 10.1186/s13041-018-0357-8 212 XieZ.DingS

Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis

The increase in circulating cobalamin levels is predominantly caused by enhanced production of haptocorrin.Several liver diseases like acute hepatitis, cirrhosis, hepatocellular carcinoma and metastatic liver disease can also be accompanied by an increase in circulating cobalamin