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Long et al

The proposed mechanism suggests that DMC inhibits mitochondrial manganese superoxide dismutase (MnSOD), leading to the production of O 2 , which in turn regulates the Akt/NF-B signaling pathway associated with cell apoptosis

The personalized treatment recommendations from the protocol consist of metabolic and lifestyle changes requiring long-term interventions to show improvement

Zuo JY, et al

10% at 10 time steps (Fig

Another GGSI (RAM2061) has been reported to slow tumor growth in a MM xenotransplantation model, dampening geranylgeranylation in vivo either alone or in combination with bortezomib [101]