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In the rat, they represent only approximately 10% of the total number of OR, while in most other species (guinea pig, monkey, and human) they represent at least a third of the opioid binding population (Dhawan et al., 2012

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doi: 10.3389/fphys.2023.1289587 Received 06 September 2023 Accepted 23 October 2023 Published 08 November 2023 Volume 14 - 2023 Edited by Murugesan Velayutham, West Virginia University, United States Reviewed by Hyun Seok Hwang, Florida State University, United States Nazmi Yara, Akdeniz University, Trkiye Updates Copyright 2023 Szyller, Antoniak, Wadowska, Bil-Lula, Hrymniak, Banasiak and Jagielski