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Explant of human or animal spinal segments have proven extremely valuable, because they overcome the ethical limitation of applying high energy trauma in-vivo and because the culture environment is largely controllable without losing the native tissue and organ structure

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Neurological symptoms such as numbness, tingling, balance problems, or cognitive changes require urgent treatment to prevent permanent complications

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CONVERT trial | JCO 2026 In locally advanced rectal cancer with uninvolved mesorectal fascia (MRF-negative), neoadjuvant CAPOX alone achieved very low local recurrence, similar DFS and OS, and less long-term toxicity compared with standard chemoradiation

These symptoms require immediate medical attention as they may indicate strangulation