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Biomarkers for the detection of aging Over the past decade, significant progress has been made in the development of novel blood biomarkers of aging

10.3892/ijo.2018.4280 21 HassanniaB.WiernickiB.IngoldI.QuF.Van HerckS.TyurinaY

12, 219227 10.1007/BF02674614 [DOI] [PubMed] [Google Scholar] Virgintino D., Errede M., Girolamo F., Capobianco C., Robertson D., Vimercati A., Serio G., Di Benedetto A., Yonekawa Y., Frei K., Roncali L

The GSH content of supporting cells was comparatively stable over these ages

Both aging and the cryopreservation process contribute to the accumulation of ROS, leading to mitochondrial dysfunction, chromosomal abnormalities, and apoptosis, which collectively diminish oocyte quality and the survival rate of ovarian tissue

This suggests that abnormalities in multiple hormone levels, including FSH, LH, and PRL, may act synergistically on the reproductive microenvironment