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The endothelium and COVID-19: an increasingly clear link brief title: endotheliopathy in COVID-19

Virus transfection IGF-1 treated SCAPs were transfected with hsa-let-7c over/low-expression lentiviruses (Shanghai Genechem Co., LTD, Shanghai, China) and thus four groups were applied in this study, i.e., Con-over group (cells transfected with over-expression control vectors), Let-7c -over group (cells transfected with hsa-let-7c over-expression lentivirus), Con-low group (cells transfected with scramble control vectors) and Let-7c -low group (cells transfected with hsa-let-7c low-expression lentivirus)

During the initial stages of cancer development, normal cells undergo transformation toward a neoplastic state, acquiring new capabilities such as unlimited replicative potential, resistance to cell death, and stimulation of angiogenesis

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Chiou J-F, Hu M-L

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