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Mechanistic studies showed that I-S1 crosses the blood-brain barrier by adsorptive transcytosis and that murine ACE2 is involved in brain and lung uptake, but not in kidney, liver, or spleen [52] (Fig

In addition, with the recognition of various modes of cell death, the original necrosis or oncotic necrosis [79] was challenged to be apoptosis [14, 15], necroptosis [16, 17], and lately ferroptosis [18, 19] and even pyroptosis [20, 21]

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