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The results at the short-term time point (1 h) suggested that uric acid may induce oxidative stress, leading to protein carbonylation in VSMCs and a high reactivity of uric acid with cellular proteins indicating that it may rapidly cause oxidative modifications

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Adding less water than the label calls for is the opposite and more dangerous problem it over-concentrates the solution and can cause an inadvertent overdose

The rationale is to ensure that the medications are well tolerated since the content of an injection cannot be removed if it causes problems

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