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Diet 23 , 6977 (2010)

Turning on cGMP-dependent pathways to treat cardiac dysfunctions: boom, bust, and beyond Trends Pharmacol Sci 35 8: 404-13

FIGURE 4 8.1 Iron metabolism dysregulation Iron is unevenly distributed in the cerebral cortex: the metal burden in motor-related nucleiincluding the basal ganglia, amygdala, substantia nigra, hippocampus, and red nucleusis significantly higher than in other neural regions (Bartzokis et al., 2007)

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Improves brain focus: Enhanced synaptic transmission and neuroplasticity support sustained attention and mental clarity

Immunosuppressive therapy: Depending on the severity of the irAE, immunosuppressive medications, such as corticosteroids (e.g., prednisone) or other immunomodulatory agents (e.g., infliximab, mycophenolate mofetil), may be used to suppress the overactive immune response and control inflammation