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Methylcobalamin is the active, methylated form

Assay Principle The low concentration of GSSG (high GSH/GSSG ratio) in tissues coupled with the need to prevent GSH oxidation during sample preparation, are important considerations for the accurate measurement of GSSG and GSH/GSSG ratios

Moreover, ATP-binding cassette transporter A1 (ABCA1) is also upregulated by LXR in macrophages, and since apoC-II, as well as apoE, apoC-I, and apoC-IV are all able to act as acceptors for cholesterol efflux from macrophages 73 , the coordinate upregulation of ABCA1 and this gene cluster may enhance cholesterol efflux from macrophages, including foam cells in the arterial wall 55

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Human islets were provided by the NIDDK-funded IIDP (RRID:SCR_014387) at the City of Hope (NIH grant 2UC4DK098085)