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The study complies with the recognized international standards and principles of the Declaration of Helsinki and has gained the approval of the institutional review board (IRB) at Notre Dame University - Louaize, with the following reference number (CNRS GRP#17)

Numerous studies have employed metabolomics techniques, yielding a range of valuable findings in this area

Examples are autoAb directed against the receptor A of endothelin-1 (ETAR) or the angiotensin-II type 1 receptor (AT1R), which were shown to affect several processes ranging from production of collagen by skin fibroblasts to angiogenesis modulation [7]

However, they can also occur in people over the age of 40 with a history of knee problems or chronic knee pain

1 The primary endpoint is change in VA of 0.2 logMAR or more from baseline after 1 year

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