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Cell Physiol Biochem 43:12731287

Proposed non-invasive biomarkers also include Oxidative Stress Index (OSI) and peroxiredoxin (PRDX4) [79]

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Secondly, local hypoxic environments are influenced by multifarious factors, including blood flow velocity, inflammation intensity, and tissue metabolic status, complicating the accurate assessment of hypoxia levels in clinical settings