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Several other mechanisms could contribute to therapy resistance, including a paradoxical increase in mitochondrial ROS production during hypoxia through a HIF-1 regulation loop (Murphy, 2009)

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Zheng J, Sato M, Mishima E, Sato H, Proneth B, Conrad M

10.3390/ijms25105492 20 ChenX.YanY.ZhangZ.ZhangF.LiuM.DuL.et al (2021)

Inflammation Bowel Dis (2010) 16(12):201221