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It is estimated that 30% of Americans over the age of 50 and 70% over the age of 70 do not produce enough stomach acid and intrinsic factors and are currently dealing with some level of B12 deficiency (17)

Particle size and zeta potential measurements were performed using a Malvern Instruments (Worcestershire, U.K.) Zetasizer Nano ZS DLS system

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This functional loss may stem from age-related phagocytic exhaustion and the direct toxicity of iron-rich A and tau aggregates toward microglia (155) Furthermore, prior cell culture studies confirm that amyloid exposure accelerates microglial senescence (156)

2017;8(8):Cd008502

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