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It improves cardiac function and ultrastructure, and inhibits MF development in DOX-induced CHF rats by upregulating extracellular matrix-metalloproteinase inhibitor (TIMP) expression (76) (Figure 2)

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Protective role of quercetin against cisplatin-induced hair cell damage in zebrafish embryos

doi: 10.1517/17425255.2013.796929

Moreover, EVs may be transferred from drug-resistant cancer cell to drug-sensitive counterparts and thus plays a role in the horizontal transfer of drug resistance in cancer cells by delivering specialized cargo which includes drug resistance-related proteins (P-gp, ABCG2, ABCA3, etc.), nucleic acids (mt DNA, mRNAs, miRNAs), onco-metabolites, antiapoptotic proteins [22, 23]

Oxidative stress: Major executioner in disease pathology, role in sperm DNA damage and preventive strategies