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49 Traditional small-molecule antioxidants have failed to alleviate oxidative stress in vivo because of poor brain compatibility, high dosage requirements, and high reactivity, limiting their clinical use

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kurroa rhizome capsules (picrolex) twice daily as a supplement with methoxsalen (a furanocoumarin drug), followed by exposure to light, significantly eliminated the vitiligo patches in 27 of the 30 patients involved in the study ( P kurroa extracts) in activating Nrf2 pathways, leading to the increased expression of detoxifying enzymes (Soni and Grover, 2019)

Thats where innovative delivery methods, like liposomal glutathione, come into play

Aging 86 , 5463 (2020)