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However, it requires long-term, weekly therapy to maintain efficacy

Mahmoudi-Lamouki et al., 2023)

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Pharmacogenetic variants and vitamin K deficiency: a risk factor or trigger for fibrosing interstitial pneumonias

Its derivative, 4-octyl itaconate (4-OI), activates the Nrf2 pathway by alkylating Keap1, thereby inducing antioxidant enzymes such as HO-1 and NQO1 to scavenge reactive oxygen species and alleviate oxidative stress in SLE