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Its ionic strength (~150 mM Na + ), physiological pH (~7.4), and overall small-molecule biomarker composition closely resemble those of plasma, while avoiding the clot formation that complicates conventional blood sampling [33,41,43]

One possibility is that oxidized glutathione directly oxidizes roGFP2 and other reduced proteins, however previous studies (Mller et al., 2017) and the current in vitro and yeast data show that direct roGFP2 oxidation by glutathione is very inefficient

The trial was stopped early for futility

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Zhang, R., Alt, F., Davidson, L., Orkin, S