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Increased NT5C2 expression by the rs72846714-A allele results in a depletion of not only intracellular 6-TGN but also guanine nucleotides (GN), resulting in an increased 6-TGN/GN ratio and increased DNA incorporation of 6-TGN despite lower absolute concentrations

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Mushtaq et al., 2016)

3.2 Current therapeutic approaches: challenges and limitations Recently, there has been a noteworthy development in the treatment approaches of MS

Ding X, et al