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In addition, inflammation and the pathophysiology of DN involve complex signaling pathway activation (Bui et al., 2020), such as NF-B pathway, The janus kinase/signal transducers and activators of transcription (JAKSTAT) pathway and nod-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome pathway

Zhang, Avni P

Fass DM, Reis SA, Ghosh B, Hennig KM, Joseph NF, Zhao WN, et al

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Cellular defence mechanisms against free radicals include control imposed by membrane structure, neutralization by glutathione, control exerted by non-enzymatic antioxidant scavengers such as vitamins A, E and C and enzymatic inactivation of oxygen derived free radicals