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The GIP receptor component of tirzepatide may interact differently with cardiovascular regulation than GLP-1 alone

Oxidized low-density lipoprotein (oxLDL) and endothelial dysfunction are key contributors to atherosclerosis, and MnSOD activity has been shown to reduce oxLDL-induced apoptosis in macrophages 253,254 , protect against endothelial dysfunction 255,256 , and inhibit LDL oxidation by endothelial cells 257

10.1371/journal.pone.0045612 84 HiguchiA.TakahashiK.HirashimaM.KawakitaT.TsubotaK

While milk thistle is generally well-tolerated, it is always advisable to consult a healthcare professional before starting any new supplement, especially for individuals with pre-existing medical conditions or those taking other medications