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Stabler 24 Patients with severe abnormalities should receive injections of 1000 g at least several times per week for 1 to 2 weeks, then weekly until clear improvement is shown, followed by monthly injections

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Patients with type 2 diabetes have a 15-30% prevalence of RLS compared to 5-10% in the general population, primarily due to diabetic peripheral neuropathy

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67 In 2018, a meta-analysis of four RCTs found significant benefits for herpetic neuralgia of locally injected methyl-B12, 1 mg on 6 days per week for 24 weeks

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