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As the authors point out, these findings may help to explain why these metabolic abnormalities occur in a cluster (such as found in the metabolic syndrome), partly because people are exposed to low doses of various POPs simultaneously

A peroxisomal glutathione transferase of Saccharomyces cerevisiae is functionally related to sulfur amino acid metabolism

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However, protonation at a different site could not only influence thiol pK a values, but additional charge effects could also contribute to the overall reactivity of the molecule (79)