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The exact upstream mechanism is not established: direct eNOS activation, modulation of available L-arginine, or interaction with regulatory transcription factors

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Canobbio I, Visconte C, Oliviero B et al (2016) Increased platelet adhesion and thrombus formation in a mouse model of Alzheimers disease

Akinrinde, A.S., Oyagbemi, A.A., Omobowale, T.O., Asenuga, E.R., and Ajibade, T.O., Alterations in blood pressure, antioxidant status and caspase 8 expression in cobalt chloride-induced cardio-renal dysfunction are reversed by Ocimum gratissimum and gallic acid in Wistar rats, J

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typhimurium activates caspase-1/4/11-GSDMD inflammasome pathway, while acetaminophen toxicity begins with its metabolic conversion to reactive chemical species, N-acetyl-p-benzoquinoneimine (NAPQI), which causes hepatocyte necrosis 47