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DW, JL, and QW assisted to consult relevant literatures, and they contributed many useful advices to this manuscript

We first validated the buffering phenotype in the follow-up studies, in which SLC25A19 exhibited milder growth fitness defect compared to the control cells in the presence of complex III inhibitor antimycin, complex I inhibitor piericidin and complex V inhibitor oligomycin than in the regular culture condition (Supplementary Fig

The E o term represents the standard potential for the redox couple at a given pH, R is the gas constant, T is the absolute temperature, F is Faraday's constant, and n is the number of electrons transferred

The emission from intracellular region covers the green and yellow channels (Figure 7AC)

Sibilla, S., et al

The decomposition of nitrosoperoxycarbonate into CO 3 and nitrogen dioxide NO 2 can initiate the selective oxidation and nitration of guanine, finally forming guaninethymidine crosslinks (Shafirovich And Geacintov 2017)