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therefore, the dietary and metabolic context matters

C Toxicol

As one of the most important lipid metabolic pathways, fatty acid oxidation (FAO) and its key rate-limiting enzyme, the carnitine palmitoyltransferase (CPT) system, regulate host immune responses and thus are of great clinical significance

leucine, isoleucine, and valine) are a special class of amino acids (AA)

MR-PRESSO applies a leave-one-out approach to identify the genetic variant(s) differentially driving the associations [41], i.e., outliers, and provide a corrected estimate after removing the outliers [42]

A thorough evaluation can help determine whether sleep disturbances might be related to the medication or if other factors such as obstructive sleep apnea, stress, caffeine intake, or other medications might be contributing