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However, when combined with insulin or sulfonylureas, the risk of hypoglycemia increases substantially, potentially affecting twenty to thirty percent of patients if doses of concurrent medications are not appropriately adjusted

(PubMed) Rennenberg RJ, Kessels AG, Schurgers LJ, van Engelshoven JM, de Leeuw PW, Kroon AA

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Toobert, D

While both hyperplastic and hypertrophic expansion increase adipose mass, new adipocyte formation through hyperplasia appears to preserve metabolic health during obesity (372)