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The addition of 5 to 20 mg/dL sodium ascorbate to the growth medium during ex vivo assays improved the ability of phagocytes to digest bacteria and increased the tumor cell killing capabilities of dendritic cell trained lymphocytes

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Finally, the oxidative stress and protein nitration causes the opening of the mitochondrial membrane transition pore (MPTP) leading to the collapse of the membrane potential and cessation of ATP synthesis, which is the cause of cell death [37, 38]

Am J Physiol Endocrinol Metab (2012) 302:E7786

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