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However, since the second World Symposium on PH in 1998, PH has been officially classified into five categories based on pathophysiology and clinical characteristics: (1) PAH, (2) PH associated with left heart disease, (3) PH associated with lung diseases and/or hypoxia, (4) PH due to pulmonary artery obstructions, and (5) PH with unclear and/or multifactorial mechanism (Fig