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First, the functional role of ferroptosis in distinct asthma subtypesspecifically pediatric asthma and asthma-COPD overlap syndrome (ACOS)has not been clearly defined

Peer review Peer review information Nature Communications thanks Weiqin Chen, Neil Kaplowitz, Hozumi Motohashi and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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The symptoms decreased from severe and moderately severe to mild

Their baseline butyrate production is often already lower than healthy controls, so even modest glutathione-induced microbiome shifts can push them into symptomatic constipation

For an unregulated compound, that assurance isn't a nice-to-have