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CONFLICT OF INTEREST The authors declare that they have no conflict of interest

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Third, our study was a multicenter prospective trial, which enhances the quality of evidence obtained compared to previous studies

This type of study can often lead to subsequent investigations of the function of the candidate biomarker and hence is called hypothesis generating

There are three important and conserved cysteine residues (Cys46, Cys53 and Cys106) in the DJ-1 protein, of which Cys53 and Cys106 are exposed

The accumulation of mutations in other core clock genes such as Clock and DEC2 (Yin et al., 2024) further suggests an evolutionary convergence in the reconfiguration of the circadian system