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483 The impact of the dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A)-regulated TGF- signaling pathway on hepatocellular carcinoma resistance provides a theoretical basis for combination targeted therapy

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Clinical trials examining GHK-Cu effects on facial hyperpigmentation have reported variable results, with some studies documenting 15-30% reductions in melanin index measurements over 8-12 week treatment periods, while others report minimal pigment-lightening effects

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In aged animals, surgery (like abdominal exploration under anesthesia) has been shown to activate microglia and cause synaptic loss in the hippocampus, correlating with memory deficits (64)

[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Li L., He M., Tang X., Huang J., Li J., Hong X., Fu H., Liu Y