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Nat Metab 5 , 735759 (2023)

& Rabbitts, T

Phase 3 tirzepatide trials show approximately 1622% body weight reduction

The latter is better, but we recommend methylcobalamin, as it includes a methyl group and directly aids in lowering homocysteine levels and in fixing nerve damage, two issues often faced by pernicious anemia and B12 deficiency patients

However, its important to note that 24 weeks, while substantial for clinical trials, represents a relatively limited timeframe for assessing lifetime exposure safety