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Despite its origins in the gastrointestinal tract, its benefits appear to reach far beyond the gut

Similar results have been observed using photodynamic therapy in lung cancer and with combination drug treatments in breast cancer, where increased NO and ROS lead to mitochondrial stress, autophagy, and apoptosis (121, 135, 136)

Statistical analysis A sample size of 300 participants provided an effective power of at least 96% for the two co-primary endpoints, and at least 43% for all confirmatory secondary endpoints, which were tested in a predefined hierarchical order (Supplementary Table 4)

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Reduction of Inflammation: The anti-inflammatory properties of both active ingredients can reduce skin inflammation, leading to calmer, less irritated skin

Thus, the decrease in cell viability may be explained by the off-target effects of CB-839 at high concentrations