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Synaptic deficits in iPSC-derived cortical interneurons in schizophrenia are mediated by NLGN2 and rescued by N-acetylcysteine

Ann Neurol 53(4):454468

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These can include non-enzymatic antioxidants such as uric acid, bilirubin, coenzyme Q10, melatonin, and vitamins A, C, E, and selenium, offering an individualized approach to enhancing cellular defenses against oxidative damage

1209 These findings indicate that the combination of CRISPR-Cas9 gene editing technology with single-cell metabolomics and human organoids holds promise for accurately monitoring cellular metabolic changes in relevant diseases

Hayami, S