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Given these findings, it is not surprising that the expression of MCTs is altered in multiple sclerosis (MS), which is the most common demyelinating disease of the CNS

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Of note, acidosis alone significantly suppresses peptide synthesis, much like hypoxia 64,65

MS is an autoimmune disease in which reactive T cells interact with antigens presented by macrophages or microglia under pathological conditions, resulting in damage to myelin sheaths and axons and ultimately neuronal loss (244246)

Hyperhomocysteinemia and Neuropathology It is worth emphasizing that the brain is particularly susceptible to oxidative stress due to its high oxygen consumption, low antioxidant capacity, and a significant concentration of polyunsaturated fatty acids that are prone to lipid peroxidation [105]